Description: Up for auction "Bone Marrow Transplantation" Ernest Beutler Hand Signed Announcement. ES-7257E Dr. Beutler was a pioneer in bone marrow transplantation for fighting cancer; made key discoveries about the role of the X chromosome in women; helped discover G6PD deficiency, the most common clinically significant enzyme deficiency of humans; improved the diagnosis and treatment of Gaucher disease; and developed cladribine, a treatment for leukemia and multiple sclerosis. In his spare time, he also wrote the original programming for the widely used software Reference Manager. "Ernie always had a sparkle in his eye, the energy of a man half his age, and a bottomless treasury of new ideas," said Dr. Richard A. Lerner, president of Scripps. Dr. Beutler developed his interest in blood as a newly commissioned lieutenant in the Army after he had finished his residency in 1953. The Korean War had illustrated the military's need for improved treatments and the prevention for malaria, and Dr. Beutler was sent to Joliet Prison in Illinois to study the severe anemia produced in some people by the malaria drug primaquine. With his colleagues Ray Dern and Alf Alving, Dr. Beutler determined that patients who developed anemia suffered a genetic deficiency of the enzyme glucose-6-phosphate dehydrogenase, or G6PD. When stressed by the drug, their red cells were destroyed, producing anemia. An estimated 400 million people worldwide are now thought to carry this genetic defect. Dr. Beutler later developed tests for the condition. After becoming chairman of the department of medicine at City of Hope National Medical Center in Duarte, Calif., in 1959, Dr. Beutler built upon a chance observation by lifelong friend Susumu Ohno by exploring the workings of the X chromosome in females. While males carry both X and Y sex chromosomes, females carry two X chromosomes, one from each parent. Because the two chromosomes carry different genetic information, Dr. Beutler deduced that one chromosome must be inactivated in each cell of the body. He demonstrated that some black women who inherited the defective gene for G6PD deficiency from only one parent had some blood cells that did not display the deficiency and others that did, indicating that different X chromosomes were being randomly inactivated in the two groups of cells. The principle was soon demonstrated for other genes on the X chromosome as well. Independently, English geneticist Mary F. Lyon demonstrated the same phenomenon in mice. The concept ultimately had a more widely applied application in explaining the origin of tumor cells. Dr. Beutler also studied genetic diseases, especially those that manifested in blood cells. One such disorder is galactosemia, a rare hereditary enzyme deficiency in which individuals are unable to metabolize galactose, a sugar found in milk.
Price: 599.99 USD
Location: Fort Lauderdale, Florida
End Time: 2025-02-13T21:28:14.000Z
Shipping Cost: 0 USD
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Return shipping will be paid by: Buyer
All returns accepted: Returns Accepted
Item must be returned within: 14 Days
Refund will be given as: Money back or replacement (buyer's choice)
Industry: Science, Inventor
Signed: Yes
